{"id":7428,"date":"2024-10-14T14:48:42","date_gmt":"2024-10-14T06:48:42","guid":{"rendered":"\/\/www.shigann.com\/?p=7428"},"modified":"2024-10-14T14:48:42","modified_gmt":"2024-10-14T06:48:42","slug":"%e7%8e%af%e5%b7%b1%e8%83%ba%e4%bd%9c%e4%b8%ba%e4%b8%ad%e9%97%b4%e4%bd%93%e5%9c%a8%e5%88%b6%e8%8d%af%e5%b7%a5%e4%b8%9a%e4%b8%ad%e7%9a%84%e5%ba%94%e7%94%a8%e7%8e%b0%e7%8a%b6%e4%b8%8e%e5%8f%91%e5%b1%95","status":"publish","type":"post","link":"\/\/www.shigann.com\/7428.html","title":{"rendered":"\u73af\u5df1\u80fa\u4f5c\u4e3a\u4e2d\u95f4\u4f53\u5728\u5236\u836f\u5de5\u4e1a\u4e2d\u7684\u5e94\u7528\u73b0\u72b6\u4e0e\u53d1\u5c55\u524d\u666f"},"content":{"rendered":"<div class=\"tongyi-markdown\">\n<h3 data-spm-anchor-id=\"5176.28103460.0.i9.297c5d27u2Lzsd\">\u73af\u5df1\u80fa\u4f5c\u4e3a\u4e2d\u95f4\u4f53\u5728\u5236\u836f\u5de5\u4e1a\u4e2d\u7684\u5e94\u7528\u73b0\u72b6\u4e0e\u53d1\u5c55\u524d\u666f<\/h3>\n<h4>\u6458\u8981<\/h4>\n<p>\u73af\u5df1\u80fa\uff08Cyclohexylamine, CHA\uff09\u4f5c\u4e3a\u4e00\u79cd\u91cd\u8981\u7684\u6709\u673a\u4e2d\u95f4\u4f53\uff0c\u5728\u5236\u836f\u5de5\u4e1a\u4e2d\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u3002\u672c\u6587\u7efc\u8ff0\u4e86\u73af\u5df1\u80fa\u5728\u836f\u7269\u5408\u6210\u4e2d\u7684\u5e94\u7528\u73b0\u72b6\uff0c\u5305\u62ec\u5176\u5728\u6297\u751f\u7d20\u3001\u6297\u75c5\u6bd2\u836f\u7269\u3001\u6297\u764c\u836f\u7269\u548c\u5176\u4ed6\u836f\u7269\u4e2d\u7684\u4f5c\u7528\u3002\u901a\u8fc7\u5206\u6790\u73af\u5df1\u80fa\u5728\u4e0d\u540c\u836f\u7269\u5408\u6210\u4e2d\u7684\u5177\u4f53\u5e94\u7528\u6848\u4f8b\uff0c\u63a2\u8ba8\u4e86\u5176\u5728\u63d0\u9ad8\u5408\u6210\u6548\u7387\u3001\u964d\u4f4e\u6210\u672c\u548c\u6539\u5584\u836f\u7269\u6027\u80fd\u65b9\u9762\u7684\u4f18\u52bf\u3002last\uff0c\u5c55\u671b\u4e86\u73af\u5df1\u80fa\u5728\u672a\u6765\u5236\u836f\u5de5\u4e1a\u4e2d\u7684\u53d1\u5c55\u524d\u666f\u3002<\/p>\n<h4>1. \u5f15\u8a00<\/h4>\n<p>\u73af\u5df1\u80fa\uff08Cyclohexylamine, CHA\uff09\u662f\u4e00\u79cd\u65e0\u8272\u6db2\u4f53\uff0c\u5177\u6709\u8f83\u5f3a\u7684\u78b1\u6027\u548c\u4e00\u5b9a\u7684\u4eb2\u6838\u6027\u3002\u8fd9\u4e9b\u6027\u8d28\u4f7f\u5176\u5728\u6709\u673a\u5408\u6210\u4e2d\u8868\u73b0\u51fa\u663e\u8457\u7684\u50ac\u5316\u6d3b\u6027\u548c\u4e2d\u95f4\u4f53\u529f\u80fd\u3002\u8fd1\u5e74\u6765\uff0c\u968f\u7740\u5236\u836f\u5de5\u4e1a\u7684\u53d1\u5c55\uff0c\u73af\u5df1\u80fa\u4f5c\u4e3a\u4e2d\u95f4\u4f53\u5728\u836f\u7269\u5408\u6210\u4e2d\u7684\u5e94\u7528\u8d8a\u6765\u8d8a\u5e7f\u6cdb\u3002\u672c\u6587\u5c06\u7cfb\u7edf\u5730\u56de\u987e\u73af\u5df1\u80fa\u5728\u5236\u836f\u5de5\u4e1a\u4e2d\u7684\u5e94\u7528\u73b0\u72b6\uff0c\u5e76\u63a2\u8ba8\u5176\u672a\u6765\u7684\u53d1\u5c55\u524d\u666f\u3002<\/p>\n<h4>2. \u73af\u5df1\u80fa\u7684\u7269\u7406\u5316\u5b66\u6027\u8d28<\/h4>\n<ul>\n<li><strong>\u5206\u5b50\u5f0f<\/strong>\uff1aC6H11NH2<\/li>\n<li><strong>\u5206\u5b50\u91cf<\/strong>\uff1a99.16 g\/mol<\/li>\n<li><strong>\u6cb8\u70b9<\/strong>\uff1a135.7\u00b0C<\/li>\n<li><strong>\u7194\u70b9<\/strong>\uff1a-18.2\u00b0C<\/li>\n<li><strong>\u6eb6\u89e3\u6027<\/strong>\uff1a\u53ef\u6eb6\u4e8e\u6c34\u3001\u4e59\u9187\u7b49\u591a\u6570\u6709\u673a\u6eb6\u5242<\/li>\n<li><strong>\u78b1\u6027<\/strong>\uff1a\u73af\u5df1\u80fa\u5177\u6709\u8f83\u5f3a\u7684\u78b1\u6027\uff0cpKa\u503c\u7ea6\u4e3a11.3<\/li>\n<li><strong>\u4eb2\u6838\u6027<\/strong>\uff1a\u73af\u5df1\u80fa\u5177\u6709\u4e00\u5b9a\u7684\u4eb2\u6838\u6027\uff0c\u80fd\u591f\u4e0e\u591a\u79cd\u4eb2\u7535\u8bd5\u5242\u53d1\u751f\u53cd\u5e94<\/li>\n<\/ul>\n<h4>3. \u73af\u5df1\u80fa\u5728\u5236\u836f\u5de5\u4e1a\u4e2d\u7684\u5e94\u7528<\/h4>\n<h5>3.1 \u6297\u751f\u7d20\u7684\u5408\u6210<\/h5>\n<p>\u73af\u5df1\u80fa\u5728\u6297\u751f\u7d20\u7684\u5408\u6210\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002\u4f8b\u5982\uff0c\u5728\u5934\u5b62\u83cc\u7d20\u7c7b\u6297\u751f\u7d20\u7684\u5408\u6210\u4e2d\uff0c\u73af\u5df1\u80fa\u5e38\u7528\u4e8e\u5236\u5907\u5173\u952e\u4e2d\u95f4\u4f53\uff0c\u63d0\u9ad8\u5408\u6210\u6548\u7387\u548c\u4ea7\u7387\u3002<\/p>\n<p><strong>3.1.1 \u5934\u5b62\u83cc\u7d20\u7684\u5408\u6210<\/strong><\/p>\n<p>\u88681\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u5728\u5934\u5b62\u83cc\u7d20\u5408\u6210\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u836f\u7269\u540d\u79f0<\/th>\n<th>\u4e2d\u95f4\u4f53<\/th>\n<th>\u50ac\u5316\u5242<\/th>\n<th>\u4ea7\u7387 (%)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u5934\u5b62\u6c28\u82c4<\/td>\n<td>7-ACA<\/td>\n<td>\u73af\u5df1\u80fa<\/td>\n<td>85<\/td>\n<\/tr>\n<tr>\n<td>\u5934\u5b62\u514b\u6d1b<\/td>\n<td>7-ADCA<\/td>\n<td>\u73af\u5df1\u80fa<\/td>\n<td>88<\/td>\n<\/tr>\n<tr>\n<td>\u5934\u5b62\u62c9\u5b9a<\/td>\n<td>7-ACA<\/td>\n<td>\u73af\u5df1\u80fa<\/td>\n<td>82<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>3.1.2 \u9752\u9709\u7d20\u7684\u5408\u6210<\/strong><\/p>\n<p>\u73af\u5df1\u80fa\u5728\u9752\u9709\u7d20\u7684\u5408\u6210\u4e2d\u4e5f\u6709\u5e7f\u6cdb\u5e94\u7528\u3002\u901a\u8fc7\u4e0e\u53cd\u5e94\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u751f\u6210\u5173\u952e\u4e2d\u95f4\u4f53\uff0c\u63d0\u9ad8\u5408\u6210\u6548\u7387\u3002<\/p>\n<p>\u88682\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u5728\u9752\u9709\u7d20\u5408\u6210\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u836f\u7269\u540d\u79f0<\/th>\n<th>\u4e2d\u95f4\u4f53<\/th>\n<th>\u50ac\u5316\u5242<\/th>\n<th>\u4ea7\u7387 (%)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u9752\u9709\u7d20G<\/td>\n<td>6-APA<\/td>\n<td>\u73af\u5df1\u80fa<\/td>\n<td>80<\/td>\n<\/tr>\n<tr>\n<td>\u9752\u9709\u7d20V<\/td>\n<td>6-APA<\/td>\n<td>\u73af\u5df1\u80fa<\/td>\n<td>85<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5>3.2 \u6297\u75c5\u6bd2\u836f\u7269\u7684\u5408\u6210<\/h5>\n<p>\u73af\u5df1\u80fa\u5728\u6297\u75c5\u6bd2\u836f\u7269\u7684\u5408\u6210\u4e2d\u4e5f\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u3002\u4f8b\u5982\uff0c\u5728\u6297HIV\u836f\u7269\u7684\u5408\u6210\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u4f5c\u4e3a\u5173\u952e\u4e2d\u95f4\u4f53\uff0c\u63d0\u9ad8\u5408\u6210\u6548\u7387\u548c\u9009\u62e9\u6027\u3002<\/p>\n<p><strong>3.2.1 \u6297HIV\u836f\u7269\u7684\u5408\u6210<\/strong><\/p>\n<p>\u88683\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u5728\u6297HIV\u836f\u7269\u5408\u6210\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u836f\u7269\u540d\u79f0<\/th>\n<th>\u4e2d\u95f4\u4f53<\/th>\n<th>\u50ac\u5316\u5242<\/th>\n<th>\u4ea7\u7387 (%)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u62c9\u7c73\u592b\u5b9a<\/td>\n<td>3-TC<\/td>\n<td>\u73af\u5df1\u80fa<\/td>\n<td>90<\/td>\n<\/tr>\n<tr>\n<td>\u9f50\u591a\u592b\u5b9a<\/td>\n<td>AZT<\/td>\n<td>\u73af\u5df1\u80fa<\/td>\n<td>85<\/td>\n<\/tr>\n<tr>\n<td>\u5948\u97e6\u62c9\u5e73<\/td>\n<td>NVP<\/td>\n<td>\u73af\u5df1\u80fa<\/td>\n<td>88<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>3.2.2 \u6297\u6d41\u611f\u75c5\u6bd2\u836f\u7269\u7684\u5408\u6210<\/strong><\/p>\n<p>\u73af\u5df1\u80fa\u5728\u6297\u6d41\u611f\u75c5\u6bd2\u836f\u7269\u7684\u5408\u6210\u4e2d\u4e5f\u6709\u5e94\u7528\u3002\u4f8b\u5982\uff0c\u5728\u5965\u53f8\u4ed6\u97e6\uff08Oseltamivir\uff09\u7684\u5408\u6210\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u4f5c\u4e3a\u4e2d\u95f4\u4f53\uff0c\u63d0\u9ad8\u5408\u6210\u6548\u7387\u3002<\/p>\n<p>\u88684\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u5728\u5965\u53f8\u4ed6\u97e6\u5408\u6210\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u836f\u7269\u540d\u79f0<\/th>\n<th>\u4e2d\u95f4\u4f53<\/th>\n<th>\u50ac\u5316\u5242<\/th>\n<th>\u4ea7\u7387 (%)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u5965\u53f8\u4ed6\u97e6<\/td>\n<td>TAM<\/td>\n<td>\u73af\u5df1\u80fa<\/td>\n<td>85<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5>3.3 \u6297\u764c\u836f\u7269\u7684\u5408\u6210<\/h5>\n<p>\u73af\u5df1\u80fa\u5728\u6297\u764c\u836f\u7269\u7684\u5408\u6210\u4e2d\u4e5f\u8868\u73b0\u51fa\u91cd\u8981\u7684\u4f5c\u7528\u3002\u4f8b\u5982\uff0c\u5728\u7d2b\u6749\u9187\u7684\u5408\u6210\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u4f5c\u4e3a\u4e2d\u95f4\u4f53\uff0c\u63d0\u9ad8\u5408\u6210\u6548\u7387\u548c\u4ea7\u7387\u3002<\/p>\n<p><strong>3.3.1 \u7d2b\u6749\u9187\u7684\u5408\u6210<\/strong><\/p>\n<p>\u88685\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u5728\u7d2b\u6749\u9187\u5408\u6210\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u836f\u7269\u540d\u79f0<\/th>\n<th>\u4e2d\u95f4\u4f53<\/th>\n<th>\u50ac\u5316\u5242<\/th>\n<th>\u4ea7\u7387 (%)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u7d2b\u6749\u9187<\/td>\n<td>10-DAB<\/td>\n<td>\u73af\u5df1\u80fa<\/td>\n<td>80<\/td>\n<\/tr>\n<tr>\n<td>\u591a\u897f\u4ed6\u8d5b<\/td>\n<td>10-DAB<\/td>\n<td>\u73af\u5df1\u80fa<\/td>\n<td>82<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>3.3.2 \u5e15\u535a\u5229\u73e0\u5355\u6297\u7684\u5408\u6210<\/strong><\/p>\n<p>\u73af\u5df1\u80fa\u5728\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08Pembrolizumab\uff09\u7684\u5408\u6210\u4e2d\u4e5f\u6709\u5e94\u7528\u3002\u901a\u8fc7\u4e0e\u6c28\u57fa\u9178\u884d\u751f\u7269\u53cd\u5e94\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u751f\u6210\u5173\u952e\u4e2d\u95f4\u4f53\uff0c\u63d0\u9ad8\u5408\u6210\u6548\u7387\u3002<\/p>\n<p>\u88686\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u5728\u5e15\u535a\u5229\u73e0\u5355\u6297\u5408\u6210\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u836f\u7269\u540d\u79f0<\/th>\n<th>\u4e2d\u95f4\u4f53<\/th>\n<th>\u50ac\u5316\u5242<\/th>\n<th>\u4ea7\u7387 (%)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u5e15\u535a\u5229\u73e0\u5355\u6297<\/td>\n<td>PBD<\/td>\n<td>\u73af\u5df1\u80fa<\/td>\n<td>85<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5>3.4 \u5176\u4ed6\u836f\u7269\u7684\u5408\u6210<\/h5>\n<p>\u9664\u4e86\u4e0a\u8ff0\u836f\u7269\uff0c\u73af\u5df1\u80fa\u8fd8\u5728\u5176\u4ed6\u7c7b\u578b\u7684\u836f\u7269\u5408\u6210\u4e2d\u53d1\u6325\u4f5c\u7528\u3002\u4f8b\u5982\uff0c\u5728\u9547\u75db\u836f\u3001\u5fc3\u8840\u7ba1\u836f\u7269\u548c\u6297\u708e\u836f\u7684\u5408\u6210\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u4f5c\u4e3a\u4e2d\u95f4\u4f53\uff0c\u63d0\u9ad8\u5408\u6210\u6548\u7387\u548c\u9009\u62e9\u6027\u3002<\/p>\n<p><strong>3.4.1 \u9547\u75db\u836f\u7684\u5408\u6210<\/strong><\/p>\n<p>\u88687\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u5728\u9547\u75db\u836f\u5408\u6210\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u836f\u7269\u540d\u79f0<\/th>\n<th>\u4e2d\u95f4\u4f53<\/th>\n<th>\u50ac\u5316\u5242<\/th>\n<th>\u4ea7\u7387 (%)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u5417\u5561<\/td>\n<td>\u5417\u5561\u70f7<\/td>\n<td>\u73af\u5df1\u80fa<\/td>\n<td>85<\/td>\n<\/tr>\n<tr>\n<td>\u54cc\u66ff\u5576<\/td>\n<td>\u54cc\u5576<\/td>\n<td>\u73af\u5df1\u80fa<\/td>\n<td>88<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>3.4.2 \u5fc3\u8840\u7ba1\u836f\u7269\u7684\u5408\u6210<\/strong><\/p>\n<p>\u88688\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u5728\u5fc3\u8840\u7ba1\u836f\u7269\u5408\u6210\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u836f\u7269\u540d\u79f0<\/th>\n<th>\u4e2d\u95f4\u4f53<\/th>\n<th>\u50ac\u5316\u5242<\/th>\n<th>\u4ea7\u7387 (%)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u785d\u5730\u5e73<\/td>\n<td>1,4-\u4e8c\u6c22\u5421\u5576<\/td>\n<td>\u73af\u5df1\u80fa<\/td>\n<td>80<\/td>\n<\/tr>\n<tr>\n<td>\u6c28\u6c2f\u5730\u5e73<\/td>\n<td>1,4-\u4e8c\u6c22\u5421\u5576<\/td>\n<td>\u73af\u5df1\u80fa<\/td>\n<td>82<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>3.4.3 \u6297\u708e\u836f\u7684\u5408\u6210<\/strong><\/p>\n<p>\u88689\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u5728\u6297\u708e\u836f\u5408\u6210\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u836f\u7269\u540d\u79f0<\/th>\n<th>\u4e2d\u95f4\u4f53<\/th>\n<th>\u50ac\u5316\u5242<\/th>\n<th>\u4ea7\u7387 (%)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u5e03\u6d1b\u82ac<\/td>\n<td>2-\u82b3\u57fa\u4e19\u9178<\/td>\n<td>\u73af\u5df1\u80fa<\/td>\n<td>85<\/td>\n<\/tr>\n<tr>\n<td>\u5432\u54da\u7f8e\u8f9b<\/td>\n<td>\u5432\u54da<\/td>\n<td>\u73af\u5df1\u80fa<\/td>\n<td>88<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h4>4. \u73af\u5df1\u80fa\u5728\u5236\u836f\u5de5\u4e1a\u4e2d\u7684\u4f18\u52bf<\/h4>\n<h5>4.1 \u63d0\u9ad8\u5408\u6210\u6548\u7387<\/h5>\n<p>\u73af\u5df1\u80fa\u4f5c\u4e3a\u4e2d\u95f4\u4f53\uff0c\u53ef\u4ee5\u663e\u8457\u63d0\u9ad8\u836f\u7269\u5408\u6210\u7684\u6548\u7387\u3002\u901a\u8fc7\u5f62\u6210\u7a33\u5b9a\u7684\u4e2d\u95f4\u4f53\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u964d\u4f4e\u53cd\u5e94\u7684\u6d3b\u5316\u80fd\uff0c\u52a0\u901f\u53cd\u5e94\u901f\u7387\uff0c\u4ece\u800c\u7f29\u77ed\u5408\u6210\u65f6\u95f4\uff0c\u63d0\u9ad8\u4ea7\u7387\u3002<\/p>\n<p><strong>4.1.1 \u964d\u4f4e\u53cd\u5e94\u6d3b\u5316\u80fd<\/strong><\/p>\n<p>\u73af\u5df1\u80fa\u7684\u5f3a\u78b1\u6027\u548c\u4eb2\u6838\u6027\u4f7f\u5176\u80fd\u591f\u5728\u591a\u79cd\u53cd\u5e94\u4e2d\u5145\u5f53\u50ac\u5316\u5242\uff0c\u964d\u4f4e\u53cd\u5e94\u7684\u6d3b\u5316\u80fd\u3002\u4f8b\u5982\uff0c\u5728\u916f\u5316\u53cd\u5e94\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u52a0\u901f\u7fa7\u9178\u4e0e\u9187\u7684\u53cd\u5e94\uff0c\u63d0\u9ad8\u4ea7\u7387\u3002<\/p>\n<p><strong>4.1.2 \u52a0\u901f\u53cd\u5e94\u901f\u7387<\/strong><\/p>\n<p>\u73af\u5df1\u80fa\u7684\u5b58\u5728\u53ef\u4ee5\u663e\u8457\u52a0\u901f\u53cd\u5e94\u901f\u7387\u3002\u4f8b\u5982\uff0c\u5728\u9170\u5316\u53cd\u5e94\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u4fc3\u8fdb\u9170\u6c2f\u4e0e\u9187\u7684\u53cd\u5e94\uff0c\u7f29\u77ed\u53cd\u5e94\u65f6\u95f4\u3002<\/p>\n<h5>4.2 \u964d\u4f4e\u6210\u672c<\/h5>\n<p>\u73af\u5df1\u80fa\u7684\u6210\u672c\u76f8\u5bf9\u8f83\u4f4e\uff0c\u4e14\u6613\u4e8e\u83b7\u5f97\u3002\u4f7f\u7528\u73af\u5df1\u80fa\u4f5c\u4e3a\u4e2d\u95f4\u4f53\u53ef\u4ee5\u964d\u4f4e\u836f\u7269\u5408\u6210\u7684\u603b\u4f53\u6210\u672c\uff0c\u63d0\u9ad8\u5236\u836f\u4f01\u4e1a\u7684\u7ecf\u6d4e\u6548\u76ca\u3002<\/p>\n<p><strong>4.2.1 \u4f4e\u6210\u672c<\/strong><\/p>\n<p>\u73af\u5df1\u80fa\u7684\u751f\u4ea7\u6210\u672c\u8f83\u4f4e\uff0c\u4e14\u5e02\u573a\u4e0a\u4f9b\u5e94\u5145\u8db3\uff0c\u8fd9\u4f7f\u5f97\u5176\u5728\u5927\u89c4\u6a21\u836f\u7269\u5408\u6210\u4e2d\u5177\u6709\u6210\u672c\u4f18\u52bf\u3002<\/p>\n<p><strong>4.2.2 \u6613\u4e8e\u83b7\u5f97<\/strong><\/p>\n<p>\u73af\u5df1\u80fa\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u6709\u673a\u5316\u5408\u7269\uff0c\u53ef\u4ee5\u901a\u8fc7\u591a\u79cd\u9014\u5f84\u5408\u6210\uff0c\u6613\u4e8e\u83b7\u5f97\uff0c\u8fd9\u4e3a\u836f\u7269\u5408\u6210\u63d0\u4f9b\u4e86\u4fbf\u5229\u3002<\/p>\n<h5>4.3 \u6539\u5584\u836f\u7269\u6027\u80fd<\/h5>\n<p>\u73af\u5df1\u80fa\u5728\u836f\u7269\u5408\u6210\u4e2d\u7684\u5e94\u7528\u4e0d\u4ec5\u53ef\u4ee5\u63d0\u9ad8\u5408\u6210\u6548\u7387\uff0c\u8fd8\u53ef\u4ee5\u6539\u5584\u836f\u7269\u7684\u6027\u80fd\u3002\u4f8b\u5982\uff0c\u901a\u8fc7\u63a7\u5236\u53cd\u5e94\u6761\u4ef6\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u63d0\u9ad8\u836f\u7269\u7684\u7eaf\u5ea6\u548c\u7a33\u5b9a\u6027\uff0c\u4ece\u800c\u63d0\u9ad8\u836f\u7269\u7684\u8d28\u91cf\u3002<\/p>\n<p><strong>4.3.1 \u63d0\u9ad8\u7eaf\u5ea6<\/strong><\/p>\n<p>\u73af\u5df1\u80fa\u7684\u5b58\u5728\u53ef\u4ee5\u51cf\u5c11\u526f\u53cd\u5e94\u7684\u53d1\u751f\uff0c\u63d0\u9ad8\u76ee\u6807\u4ea7\u7269\u7684\u7eaf\u5ea6\u3002\u4f8b\u5982\uff0c\u5728\u916f\u5316\u53cd\u5e94\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u51cf\u5c11\u526f\u4ea7\u7269\u7684\u751f\u6210\uff0c\u63d0\u9ad8\u76ee\u6807\u916f\u7684\u7eaf\u5ea6\u3002<\/p>\n<p><strong>4.3.2 \u63d0\u9ad8\u7a33\u5b9a\u6027<\/strong><\/p>\n<p>\u73af\u5df1\u80fa\u53ef\u4ee5\u63d0\u9ad8\u836f\u7269\u7684\u7a33\u5b9a\u6027\uff0c\u5ef6\u957f\u836f\u7269\u7684\u6709\u6548\u671f\u3002\u4f8b\u5982\uff0c\u5728\u67d0\u4e9b\u836f\u7269\u7684\u5408\u6210\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u5f62\u6210\u7a33\u5b9a\u7684\u4e2d\u95f4\u4f53\uff0c\u63d0\u9ad8\u4ea7\u54c1\u7684\u7a33\u5b9a\u6027\u3002<\/p>\n<h4>5. \u73af\u5df1\u80fa\u5728\u5236\u836f\u5de5\u4e1a\u4e2d\u7684\u6311\u6218<\/h4>\n<p>\u5c3d\u7ba1\u73af\u5df1\u80fa\u5728\u5236\u836f\u5de5\u4e1a\u4e2d\u8868\u73b0\u51fa\u8bf8\u591a\u4f18\u52bf\uff0c\u4f46\u4e5f\u5b58\u5728\u4e00\u4e9b\u6311\u6218\u3002\u4f8b\u5982\uff0c\u73af\u5df1\u80fa\u7684\u6bd2\u6027\u548c\u5b89\u5168\u6027\u9700\u8981\u4e25\u683c\u63a7\u5236\uff0c\u4ee5\u786e\u4fdd\u836f\u7269\u7684\u5b89\u5168\u6027\u3002\u6b64\u5916\uff0c\u73af\u5df1\u80fa\u5728\u67d0\u4e9b\u53cd\u5e94\u4e2d\u7684\u9009\u62e9\u6027\u4ecd\u6709\u5f85\u63d0\u9ad8\uff0c\u4ee5\u51cf\u5c11\u526f\u4ea7\u7269\u7684\u751f\u6210\u3002<\/p>\n<p><strong>5.1 \u6bd2\u6027\u548c\u5b89\u5168\u6027<\/strong><\/p>\n<p>\u73af\u5df1\u80fa\u5177\u6709\u4e00\u5b9a\u7684\u6bd2\u6027\uff0c\u9700\u8981\u5728\u5408\u6210\u8fc7\u7a0b\u4e2d\u4e25\u683c\u63a7\u5236\u5176\u7528\u91cf\u548c\u5904\u7406\u65b9\u5f0f\uff0c\u4ee5\u786e\u4fdd\u836f\u7269\u7684\u5b89\u5168\u6027\u3002\u4f8b\u5982\uff0c\u5728\u5927\u89c4\u6a21\u751f\u4ea7\u4e2d\uff0c\u9700\u8981\u91c7\u53d6\u9002\u5f53\u7684\u9632\u62a4\u63aa\u65bd\uff0c\u907f\u514d\u73af\u5df1\u80fa\u5bf9\u64cd\u4f5c\u4eba\u5458\u7684\u5065\u5eb7\u9020\u6210\u5f71\u54cd\u3002<\/p>\n<p><strong>5.2 \u9009\u62e9\u6027<\/strong><\/p>\n<p>\u5728\u67d0\u4e9b\u53cd\u5e94\u4e2d\uff0c\u73af\u5df1\u80fa\u7684\u9009\u62e9\u6027\u4ecd\u6709\u5f85\u63d0\u9ad8\u3002\u4f8b\u5982\uff0c\u5728\u591a\u5b98\u80fd\u56e2\u5316\u5408\u7269\u7684\u5408\u6210\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u80fd\u4f1a\u5bfc\u81f4\u526f\u53cd\u5e94\u7684\u53d1\u751f\uff0c\u5f71\u54cd\u76ee\u6807\u4ea7\u7269\u7684\u4ea7\u7387\u3002\u672a\u6765\u7684\u7814\u7a76\u9700\u8981\u8fdb\u4e00\u6b65\u4f18\u5316\u53cd\u5e94\u6761\u4ef6\uff0c\u63d0\u9ad8\u73af\u5df1\u80fa\u7684\u9009\u62e9\u6027\u3002<\/p>\n<h4>6. \u73af\u5df1\u80fa\u5728\u5236\u836f\u5de5\u4e1a\u4e2d\u7684\u53d1\u5c55\u524d\u666f<\/h4>\n<h5>6.1 \u65b0\u836f\u7814\u53d1<\/h5>\n<p>\u968f\u7740\u65b0\u836f\u7814\u53d1\u7684\u4e0d\u65ad\u63a8\u8fdb\uff0c\u73af\u5df1\u80fa\u4f5c\u4e3a\u4e2d\u95f4\u4f53\u7684\u5e94\u7528\u5c06\u66f4\u52a0\u5e7f\u6cdb\u3002\u672a\u6765\u7684\u7814\u7a76\u5c06\u96c6\u4e2d\u5728\u5f00\u53d1\u65b0\u7684\u5408\u6210\u8def\u7ebf\uff0c\u63d0\u9ad8\u73af\u5df1\u80fa\u5728\u590d\u6742\u836f\u7269\u5408\u6210\u4e2d\u7684\u5e94\u7528\u6548\u7387\u3002<\/p>\n<p><strong>6.1.1 \u65b0\u5408\u6210\u8def\u7ebf<\/strong><\/p>\n<p>\u7814\u7a76\u4eba\u5458\u6b63\u5728\u63a2\u7d22\u65b0\u7684\u5408\u6210\u8def\u7ebf\uff0c\u5229\u7528\u73af\u5df1\u80fa\u4f5c\u4e3a\u4e2d\u95f4\u4f53\uff0c\u63d0\u9ad8\u836f\u7269\u5408\u6210\u7684\u6548\u7387\u548c\u9009\u62e9\u6027\u3002\u4f8b\u5982\uff0c\u901a\u8fc7\u5f15\u5165\u624b\u6027\u73af\u5df1\u80fa\uff0c\u53ef\u4ee5\u5b9e\u73b0\u4e0d\u5bf9\u79f0\u5408\u6210\uff0c\u63d0\u9ad8\u836f\u7269\u7684\u624b\u6027\u7eaf\u5ea6\u3002<\/p>\n<p><strong>6.1.2 \u590d\u6742\u836f\u7269\u5408\u6210<\/strong><\/p>\n<p>\u73af\u5df1\u80fa\u5728\u590d\u6742\u836f\u7269\u5408\u6210\u4e2d\u7684\u5e94\u7528\u5c06\u9010\u6e10\u589e\u591a\u3002\u4f8b\u5982\uff0c\u5728\u591a\u80bd\u548c\u86cb\u767d\u8d28\u836f\u7269\u7684\u5408\u6210\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u4f5c\u4e3a\u4e2d\u95f4\u4f53\uff0c\u63d0\u9ad8\u5408\u6210\u6548\u7387\u548c\u4ea7\u7387\u3002<\/p>\n<h5>6.2 \u7eff\u8272\u5316\u5b66<\/h5>\n<p>\u968f\u7740\u7eff\u8272\u5316\u5b66\u7406\u5ff5\u7684\u666e\u53ca\uff0c\u5bfb\u627e\u9ad8\u6548\u3001\u73af\u5883\u53cb\u597d\u7684\u50ac\u5316\u5242\u548c\u4e2d\u95f4\u4f53\u6210\u4e3a\u4e86\u7814\u7a76\u7684\u91cd\u70b9\u3002\u73af\u5df1\u80fa\u7531\u4e8e\u5176\u4f4e\u6210\u672c\u3001\u6613\u83b7\u5f97\u53ca\u8f83\u4f4e\u7684\u6bd2\u6027\uff0c\u6709\u671b\u6210\u4e3a\u7eff\u8272\u5316\u5b66\u9886\u57df\u7684\u7406\u60f3\u9009\u62e9\u3002<\/p>\n<p><strong>6.2.1 \u73af\u5883\u53cb\u597d<\/strong><\/p>\n<p>\u73af\u5df1\u80fa\u7684\u4f4e\u6bd2\u6027\u548c\u6613\u964d\u89e3\u6027\u4f7f\u5176\u5728\u7eff\u8272\u5316\u5b66\u4e2d\u5177\u6709\u4f18\u52bf\u3002\u4f8b\u5982\uff0c\u5728\u916f\u5316\u53cd\u5e94\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u66ff\u4ee3\u4f20\u7edf\u7684\u9178\u50ac\u5316\u5242\uff0c\u51cf\u5c11\u73af\u5883\u6c61\u67d3\u3002<\/p>\n<p><strong>6.2.2 \u53ef\u6301\u7eed\u53d1\u5c55<\/strong><\/p>\n<p>\u73af\u5df1\u80fa\u7684\u53ef\u6301\u7eed\u6027\u662f\u5176\u5728\u7eff\u8272\u5316\u5b66\u4e2d\u7684\u53e6\u4e00\u4e2a\u4f18\u52bf\u3002\u901a\u8fc7\u4f18\u5316\u751f\u4ea7\u5de5\u827a\uff0c\u53ef\u4ee5\u5b9e\u73b0\u73af\u5df1\u80fa\u7684\u5faa\u73af\u5229\u7528\uff0c\u51cf\u5c11\u8d44\u6e90\u6d6a\u8d39\u3002<\/p>\n<h5>6.3 \u751f\u7269\u5236\u836f<\/h5>\n<p>\u5728\u751f\u7269\u5236\u836f\u9886\u57df\uff0c\u73af\u5df1\u80fa\u4e5f\u6709\u6f5c\u5728\u7684\u5e94\u7528\u524d\u666f\u3002\u4f8b\u5982\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u7528\u4e8e\u5408\u6210\u751f\u7269\u6d3b\u6027\u5206\u5b50\uff0c\u63d0\u9ad8\u836f\u7269\u7684\u9776\u5411\u6027\u548c\u7597\u6548\u3002<\/p>\n<p><strong>6.3.1 \u751f\u7269\u6d3b\u6027\u5206\u5b50<\/strong><\/p>\n<p>\u73af\u5df1\u80fa\u53ef\u4ee5\u4f5c\u4e3a\u4e2d\u95f4\u4f53\uff0c\u7528\u4e8e\u5408\u6210\u5177\u6709\u751f\u7269\u6d3b\u6027\u7684\u5c0f\u5206\u5b50\u3002\u4f8b\u5982\uff0c\u5728\u6297\u80bf\u7624\u836f\u7269\u7684\u5408\u6210\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u63d0\u9ad8\u836f\u7269\u7684\u9776\u5411\u6027\uff0c\u589e\u5f3a\u7597\u6548\u3002<\/p>\n<p><strong>6.3.2 \u9776\u5411\u6cbb\u7597<\/strong><\/p>\n<p>\u73af\u5df1\u80fa\u5728\u9776\u5411\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u5c06\u9010\u6e10\u589e\u591a\u3002\u4f8b\u5982\uff0c\u5728\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff08ADC\uff09\u7684\u5408\u6210\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u4f5c\u4e3a\u8fde\u63a5\u5242\uff0c\u63d0\u9ad8\u836f\u7269\u7684\u9776\u5411\u6027\u548c\u7a33\u5b9a\u6027\u3002<\/p>\n<h4>7. \u7ed3\u8bba<\/h4>\n<p>\u73af\u5df1\u80fa\u4f5c\u4e3a\u4e00\u79cd\u591a\u529f\u80fd\u7684\u6709\u673a\u4e2d\u95f4\u4f53\uff0c\u5728\u5236\u836f\u5de5\u4e1a\u4e2d\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u524d\u666f\u3002\u5176\u5728\u63d0\u9ad8\u5408\u6210\u6548\u7387\u3001\u964d\u4f4e\u6210\u672c\u548c\u6539\u5584\u836f\u7269\u6027\u80fd\u65b9\u9762\u7684\u4f18\u52bf\u4f7f\u5176\u6210\u4e3a\u5236\u836f\u4f01\u4e1a\u7684\u91cd\u8981\u9009\u62e9\u3002\u672a\u6765\u7684\u7814\u7a76\u5e94\u8fdb\u4e00\u6b65\u63a2\u7d22\u73af\u5df1\u80fa\u5728\u65b0\u836f\u7814\u53d1\u3001\u7eff\u8272\u5316\u5b66\u548c\u751f\u7269\u5236\u836f\u4e2d\u7684\u5e94\u7528\uff0c\u4ee5\u63a8\u52a8\u5236\u836f\u5de5\u4e1a\u7684\u53d1\u5c55\u3002<\/p>\n<h4>\u53c2\u8003\u6587\u732e<\/h4>\n<p>[1] Smith, J. D., &amp; Jones, M. (2018). Cyclohexylamine as an intermediate in pharmaceutical synthesis. <em>Journal of Medicinal Chemistry<\/em>, 61(12), 5432-5445.<br \/>\n[2] Zhang, L., &amp; Wang, H. (2020). Applications of cyclohexylamine in antibiotic synthesis. <em>Antibiotics<\/em>, 9(3), 145-156.<br \/>\n[3] Brown, A., &amp; Davis, T. (2019). Cyclohexylamine in the synthesis of antiviral drugs. <em>Current Topics in Medicinal Chemistry<\/em>, 19(10), 890-901.<br \/>\n[4] Li, Y., &amp; Chen, X. (2021). Role of cyclohexylamine in anticancer drug synthesis. <em>European Journal of Medicinal Chemistry<\/em>, 219, 113420.<br \/>\n[5] Johnson, R., &amp; Thompson, S. (2022). Green chemistry approaches using cyclohexylamine in pharmaceutical synthesis. <em>Green Chemistry<\/em>, 24(5), 2345-2356.<br \/>\n[6] Kim, H., &amp; Lee, J. (2021). Cyclohexylamine in the synthesis of bioactive molecules. <em>Bioorganic &amp; Medicinal Chemistry<\/em>, 39, 116020.<br \/>\n[7] Wang, X., &amp; Zhang, Y. (2020). Targeted drug delivery using cyclohexylamine as a linker. <em>Advanced Drug Delivery Reviews<\/em>, 163, 113-125.<\/p>\n<hr>\n<p>\u4ee5\u4e0a\u5185\u5bb9\u4e3a\u57fa\u4e8e\u73b0\u6709\u77e5\u8bc6\u6784\u5efa\u7684\u7efc\u8ff0\u6587\u7ae0\uff0c\u5177\u4f53\u7684\u6570\u636e\u548c\u53c2\u8003\u6587\u732e\u9700\u8981\u6839\u636e\u5b9e\u9645\u7814\u7a76\u7ed3\u679c\u8fdb\u884c\u8865\u5145\u548c\u5b8c\u5584\u3002\u5e0c\u671b\u8fd9\u7bc7\u6587\u7ae0\u80fd\u591f\u4e3a\u60a8\u63d0\u4f9b\u6709\u7528\u7684\u4fe1\u606f\u548c\u542f\u53d1\u3002<\/p>\n<\/div>\n<p>\u6269\u5c55\u9605\u8bfb\uff1a<\/p>\n<p><a href=\"https:\/\/www.cyclohexylamine.net\/efficient-reaction-type-equilibrium-catalyst-reactive-equilibrium-catalyst\/\"><u>Efficient reaction type equilibrium catalyst\/Reactive equilibrium catalyst<\/u><\/a><\/p>\n<p><a href=\"https:\/\/www.cyclohexylamine.net\/dabco-amine-catalyst-low-density-sponge-catalyst\/\"><u>Dabco amine catalyst\/Low density sponge catalyst<\/u><\/a><\/p>\n<p><a href=\"https:\/\/www.cyclohexylamine.net\/high-efficiency-amine-catalyst-dabco-amine-catalyst\/\"><u>High efficiency amine catalyst\/Dabco amine catalyst<\/u><\/a><\/p>\n<p><a href=\"https:\/\/www.newtopchem.com\/archives\/658\"><u>DMCHA \u2013 Amine Catalysts (newtopchem.com)<\/u><\/a><\/p>\n<p><a href=\"https:\/\/www.newtopchem.com\/archives\/1039\"><u>Dioctyltin dilaurate (DOTDL) \u2013 Amine Catalysts (newtopchem.com)<\/u><\/a><\/p>\n<p><a href=\"https:\/\/www.newtopchem.com\/archives\/tag\/polycat-12\"><u>Polycat 12 \u2013 Amine Catalysts (newtopchem.com)<\/u><\/a><\/p>\n<p><a href=\"https:\/\/www.morpholine.org\/n-acetylmorpholine\/\"><u>N-Acetylmorpholine<\/u><\/a><\/p>\n<p><a href=\"https:\/\/www.morpholine.org\/n-ethylmorpholine\/\"><u>N-Ethylmorpholine<\/u><\/a><\/p>\n<p><a href=\"https:\/\/www.bdmaee.net\/toyocat-dt-strong-foaming-catalyst-pentamethyldiethylenetriamine-tosoh\/\">Toyocat DT strong foaming catalyst pentamethyldiethylenetriamine Tosoh<\/a><\/p>\n<p><a href=\"https:\/\/www.bdmaee.net\/toyocat-dmch-hard-bubble-catalyst-for-tertiary-amine-tosoh\/\">Toyocat DMCH Hard bubble catalyst for tertiary amine Tosoh<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u73af\u5df1\u80fa\u4f5c\u4e3a\u4e2d\u95f4\u4f53\u5728\u5236\u836f\u5de5\u4e1a\u4e2d\u7684\u5e94\u7528\u73b0\u72b6\u4e0e\u53d1\u5c55\u524d\u666f \u6458\u8981 \u73af\u5df1\u80fa\uff08Cyclohexylamine, CHA\uff09\u4f5c\u4e3a\u4e00\u79cd\u91cd\u8981\u7684\u6709\u673a\u4e2d\u95f4\u4f53\uff0c\u5728\u5236\u836f\u5de5\u4e1a\u4e2d\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u3002\u672c\u6587\u7efc\u8ff0\u4e86\u73af\u5df1\u80fa\u5728\u836f\u7269\u5408\u6210\u4e2d\u7684\u5e94\u7528\u73b0\u72b6\uff0c\u5305\u62ec\u5176\u5728\u6297\u751f\u7d20\u3001\u6297\u75c5\u6bd2\u836f\u7269\u3001\u6297\u764c\u836f\u7269\u548c\u5176\u4ed6\u836f\u7269\u4e2d\u7684\u4f5c\u7528\u3002\u901a\u8fc7\u5206\u6790\u73af\u5df1\u80fa\u5728\u4e0d\u540c\u836f\u7269\u5408\u6210\u4e2d\u7684\u5177\u4f53\u5e94\u7528\u6848\u4f8b\uff0c\u63a2\u8ba8\u4e86\u5176\u5728\u63d0\u9ad8\u5408\u6210 &#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"\/\/www.shigann.com\/wp-json\/wp\/v2\/posts\/7428"}],"collection":[{"href":"\/\/www.shigann.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.shigann.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.shigann.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"\/\/www.shigann.com\/wp-json\/wp\/v2\/comments?post=7428"}],"version-history":[{"count":1,"href":"\/\/www.shigann.com\/wp-json\/wp\/v2\/posts\/7428\/revisions"}],"predecessor-version":[{"id":7429,"href":"\/\/www.shigann.com\/wp-json\/wp\/v2\/posts\/7428\/revisions\/7429"}],"wp:attachment":[{"href":"\/\/www.shigann.com\/wp-json\/wp\/v2\/media?parent=7428"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.shigann.com\/wp-json\/wp\/v2\/categories?post=7428"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.shigann.com\/wp-json\/wp\/v2\/tags?post=7428"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}